How to avoid hard coding in if condition of python script

I am new to python. I have query regarding un-hardcoding object names(if condition) in python script. I have fruit = [ Apple, Mango, Pineapple, Banana, Oranges] and size = [ small, medium , big] Currently I write code as below:

if (fruit == apple, size == small): 
   statement 1
   statement 2
elif (fruit == apple, size == medium):
   statement 1
   statement 2
elif (fruit == apple, size == big):
   statement 1
   statement 2
elif (fruit == Mango, size == small):
   statement 1
   statement 2
elif (fruit == Mango, size = medium):
   statement 1
   statement 2

How can I avoid writing multiple if...else conditions?